He’s had a long, wavy coat for months and it’s now well past winter. Simon, a sweet-natured gelding in his late teens, looks shaggy. Cushing syndrome can also cause high blood pressure, high blood sugar levels, or even diabetes. This can lead to symptoms such as weight gain, easy bruising, weakness, drowsiness, and fluid retention.

One of the first signs of Cushing syndrome, is the loss of this diurnal variation.Cushing syndrome: In this condition, the cancer cells make ACTH, a hormone that causes the adrenal glands to make cortisol. A pot-bellied appearance.Left untreated dogs with Cushing’s are predisposed to a number of internal problems, including high blood pressure, urinary tract infections, urinary stones, pancreatitis, clot formation/stroke, diabetes, and vision loss, so early diagnosis and control are important to preventing the majority of the serious complications of this disease.Initial Screening: First-Line Biochemical Tests In healthy individuals, the level of serum cortisol reaches a peak in the morning (7-9 am) and reach the lowest level between bedtime and 2 am. What are the first signs of cushing Signs of Cushing's syndrome include: Failure or later shedding of the winter coat that may become really long, matted and curly especially around the legs.